– One step site-specific antibody fragment conjugation using SNAP tag technology. Hussain A.F., Kampmeier F., Meinhold-Heerlein I., Barth S. ![]() – Identification of an atypically posttranslational modified autoantigen as the target of B-cell receptors from ABC-type diffuse large B-cell lymphoma. ![]() Thurner L., Hartmann S., Bewarder M., Fadle N., Regitz E., Körbel C., Schormann C., Quiroga N., Kemele M., Klapper W., Rosenwald A., Trümper L., Bohle R.M., Nimmesgern A., Laschke M.W., Barth S., Kubuschock B., Kaddu-Mulindwa D., Hansmann M.L., Pöschel V., Held G., Murawski N., Stilgenbauer S., Neumann F., Preuss K.D., Pfreundschuh M. Recombinant fusion proteins are mainly expressed in bacterial or mammalian cells and subsequently characterized in experimental settings, both in vitro on cell lines or primary material of patients and in vivo in transgenic/tumor-bearing mouse models. Paolo Carloni, Institute for Advanced Simulation, Forschungszentrum Jülich, Germany. Novel fusion proteins will be designed using advanced supercomputing tools to model dynamic interactions of proteins, in close collaboration with Prof. Tur, Experimental Pathology and Immunotherapy, Institute for Pathology, University Hospital Giessen and Marburg, Germany, b) Dr Peter Duncan, Afrobodies, South Africa. Novel methods for selection of antibodies are developed in close collaboration with a) Dr. The main characteristics of these novel agents are: a) disease-specific activities, b) reduced unspecific side effects, and c) reduced immunogenicity. The major aim of our research is the use of medical biotechnology methods including antibody technologies, protein engineering & expression, to develop and evaluate knowledge-based innovative recombinant immunodiagnostics and therapeutics. South African Research Chair in Cancer Biotechnology Division of Chemical & Systems Biology Department of Integrative Biomedical Sciences Member Member and Executive Director, Medical Biotechnology and Immunotherapy Unit Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town. ![]() Selected publications | Contact details | Group members | Collaborations Medical Biotechnology & Immunotherapy Research Unit
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